TY - NEWS
TI - An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis.
AU - Peters, Brian M.
AU - Luna Tapia, Arturo
AU - Tournu, Héléne
AU - Rybak, Jeffrey M.
AU - Rogers, David P.
AU - Palmer, Glen E.
AB - We recently reported that a Candida albicans endosomal trafficking mutant continues to grow after treatment with the azole antifungals. Herein, we report that the vps21Δ/Δ mutant does not have a survival advantage over wild-type isolates after fluconazole treatment in a mouse model of vaginal candidiasis. Furthermore, loss of VPS21 does not synergize with established mechanisms of azole resistance, such as overexpression of efflux pumps or of Erg11p, the target enzyme of the azoles. In summary, although loss of VPS21 function enhances C. albicans survival after azole treatment in vitro, it does not seem to affect azole susceptibility in vivo.
DA - 2019-09-24
KW - Azoles
KW - Candida albicans
KW - Resistance
KW - Tolerance
KW - Vaginal candidiasis
KW - Vps21p
PB - Estados Unidos  Antimicrobial Agents and Chemotherapy, 2017.
UR - https://repositorio.unisucre.edu.co/handle/001/792
ER -