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Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals.

dc.contributor.authorLuna Tapia, Arturospa
dc.contributor.authorKerns, Morgan E.spa
dc.contributor.authorJursic, Branko S.spa
dc.contributor.authorEberle, Karen E.spa
dc.contributor.authorPalmer, Glen E.spa
dc.coverage.spatialColombiaspa
dc.date.accessioned2019-10-02T16:38:52Zspa
dc.date.available2019-10-02T16:38:52Zspa
dc.date.issued2019-10-02spa
dc.identifier.citationLuna, A., Kerns, M.E., Eberle, K.E., Jursic, B.S. & Palmer, G.E. (2015). Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals. Antimicrobial Agents and Chemotherapy . 59(4), 2410 – 2420.spa
dc.identifier.issn1535-9786spa
dc.identifier.urihttps://repositorio.unisucre.edu.co/handle/001/817spa
dc.descriptionArtículo digital.spa
dc.description.abstractThe purpose of this study was to characterize the effects of azole treatment upon the integrity of the Candida albicans vacuole and to determine whether, in turn, vacuolar trafficking influences azole susceptibility. Profound fragmentation of the C. albicans vacuole can be observed as an early consequence of azole treatment, and it precedes significant growth inhibition. In addition, a C. albicans vps21/ mutant, blocked in membrane trafficking through the late endosomal prevacuolar compartment (PVC), is able to grow significantly more than the wild type in the presence of several azole antifungals under standard susceptibility testing conditions. F.eng
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherEstados Unidos: Antimicrobial Agents and Chemotherapy , 2015.spa
dc.relation.ispartofRevistaspa
dc.rightsDerechos Reservados - Universidad de Sucre, 2019spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourcehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356793/pdf/zac2410.pdf.spa
dc.titleTrafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals.spa
dc.typeArtículo de revistaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.identifier.doi10.1128/AAC.04239-14spa
dc.relation.referencesVandeputte P, Ferrari S, Coste AT. 2012. Antifungal resistance and new strategies to control fungal infections. Int J Microbiol 2012:713687. http: //dx.doi.org/10.1155/2012/713687.spa
dc.relation.referencesMarichal P, Koymans L, Willemsens S, Bellens D, Verhasselt P, Luyten WH, Borgers M, Ramaekers F, Odds FC, Bossche HV. 1999. Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans. Microbiology 145:2701– 2713.spa
dc.relation.referencesPerea S, Lopez-Ribot JL, Kirkpatrick WR, McAtee RK, Santillan RA, Martinez M, Calabrese D, Sanglard D, Patterson TF. 2001. Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 45:2676 –2684. http://dx.doi.org/10.1128/AAC.45.10.2676 -2684.2001.spa
dc.relation.referencesWhite TC. 1997. Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrob Agents Chemother 41:1482–1487.spa
dc.relation.referencesSanglard D, Ischer F, Monod M, Bille J. 1997. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143:405–416. http://dx.doi.org/10.1099/00221287-143-2-405.spa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.subject.proposalCandida albicansspa
dc.subject.proposalAntifungalsspa
dc.subject.proposalAzolespa
dc.contributor.corporatenameAmerican Society for Microbiology.spa
dc.type.contentTextspa
dc.type.redcolhttp://purl.org/coar/resource_type/c_2df8fbb1spa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa


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Derechos Reservados - Universidad de Sucre, 2019
Except where otherwise noted, this item's license is described as Derechos Reservados - Universidad de Sucre, 2019