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dc.contributor.authorRodas, Juan D.spa
dc.contributor.authorKautz, Tiffanyspa
dc.contributor.authorCamacho, Erwinspa
dc.contributor.authorPaternina, Luisspa
dc.contributor.authorDíaz, Francisco J.spa
dc.contributor.authorTesh, Robertspa
dc.contributor.authorWeaver, Scott C.spa
dc.contributor.authorBlanco, Pedrospa
dc.contributor.authorGuzmán, Hildaspa
dc.coverage.spatialColombiaspa
dc.date.accessioned2019-09-27T15:55:42Zspa
dc.date.available2019-09-27T15:55:42Zspa
dc.date.issued2019-09-27spa
dc.identifier.citationRodas, J.D., Kautz, T., Camacho, E., Paternina, L., Guzmán, H., Díaz, F.J., Blanco, P., Tesh, R. & Weaver S.C. ( 2016). Genetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014–2015 Epidemic. American Journal of Tropical Medicine and Hygiene . 95(3), 639–646.spa
dc.identifier.issn0002-9637spa
dc.identifier.urihttps://repositorio.unisucre.edu.co/handle/001/802spa
dc.descriptionArtículo digitalspa
dc.description.abstractChikungunya fever, an acute and often chronic arthralgic disease caused by the mosquito-borne alphavirus,chikungunya virus (CHIKV), spread into the Americas in late 2013. Since then it has caused epidemics in nearly all New World countries, the second largest being Colombia with over 450,000 suspected cases beginning in September, 2014, and focused in Bolivar Department in the north. We examined 32 human sera from suspected cases, including diverse age groups and both genders, and sequenced the CHIKV envelope glycoprotein genes, known determinants of vector host range. As expected for Asian lineage CHIKV strains, these isolates lacked known Aedes albopictus–adaptive mutations. All the Colombian strains were closely related to those from the Virgin Islands, Saint Lucia, Mexico, Puerto Rico, and Brazil, consistent with a single, point-source introduction from the southeast Asia/Pacific region. Two substitutions in the E2 and E1 envelope glycoprotein genes were found in the Colombian strains, especially E1-K211E involving a residue shown previously to affect epistatically the penetrance of the E1-A226V A. albopictus–adaptive substitution. We also identified two amino acid substitutions unique to all American CHIKV sequences: E2-V368A and 6K-L20M. Only one codon, 6K-47, had a high nonsynonymous substitution rate suggesting positive selection.eng
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherEstados Unidos: The American Journal of Tropical Medicine and Hygiene , 2016.spa
dc.relation.ispartofRevistaspa
dc.rightsDerechos Reservados - Universidad de Sucre, 2019spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourcehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014272/pdf/spa
dc.titleGenetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014–2015 Epidemic.spa
dc.typeArtículo de revistaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.identifier.doi10.4269/ajtmh.16-0091spa
dc.relation.referencesCardona-Ospina JA, Vera-Polania F, Rodriguez-Morales AJ, 2015. Chikungunya or not, differential diagnosis and the importance of laboratory confirmation for clinical and epidemiological research: comment on the article by Rosario et al. Clin Rheumatol 35: 829–830.spa
dc.relation.referencesTsetsarkin KA, Chen R, Sherman MB, Weaver SC, 2011. Chikungunya virus: evolution and genetic determinants of emergence. Curr Opin Virol 1: 310–317.Tsetsarkin KA, Chen R, Sherman MB, Weaver SC, 2011. Chikungunya virus: evolution and genetic determinants of emergence. Curr Opin Virol 1: 310–317.spa
dc.relation.referencesVoss JE, Vaney M-C, Duquerroy S, Vonrhein C, Girard-Blanc C, Crublet E, Thompson A, Bricogne G, Rey FA, 2010. Glycoprotein organization of chikungunya virus particles revealed by X-ray crystallography. Nature 468: 709–712.spa
dc.relation.referencesWeaver SC, Lecuit M, 2015. Chikungunya virus and the global spread of a mosquito-borne disease. N Engl J Med 372: 1231–1239.spa
dc.relation.referencesPorta J, Jose J, Roehrig JT, Blair CD, Kuhn RJ, Rossmann MG, 2014. Locking and blocking the viral landscape of an alphavirus with neutralizing antibodies. J Virol 88: 9616–9623.spa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.subject.proposalChikungunyaspa
dc.subject.proposalCHIKVspa
dc.subject.proposalAlphavirusspa
dc.subject.proposalRNAspa
dc.subject.proposalEpidemicspa
dc.contributor.corporatenameThe American Society of Tropical Medicine and Hygiene.spa
dc.type.contentTextspa
dc.type.redcolhttp://purl.org/coar/resource_type/c_2df8fbb1spa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa


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