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dc.contributor.authorPeters, Brian M.spa
dc.contributor.authorLuna Tapia, Arturospa
dc.contributor.authorTournu, Hélénespa
dc.contributor.authorRybak, Jeffrey M.spa
dc.contributor.authorRogers, David P.spa
dc.contributor.authorPalmer, Glen E.spa
dc.coverage.spatialColombiaspa
dc.date.accessioned2019-09-24T22:14:35Zspa
dc.date.available2019-09-24T22:14:35Zspa
dc.date.issued2019-09-24spa
dc.identifier.citationPeters, B.M., Luna, A., Tournu, H., Rybak, J.M., Rogers, P.D. & Palmer, G.E. (2017). An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis. Antimicrobial Agents and Chemotherapy . 61(6).spa
dc.identifier.issn1098-6596spa
dc.identifier.urihttps://repositorio.unisucre.edu.co/handle/001/792spa
dc.descriptionArtículo digital.spa
dc.description.abstractWe recently reported that a Candida albicans endosomal trafficking mutant continues to grow after treatment with the azole antifungals. Herein, we report that the vps21Δ/Δ mutant does not have a survival advantage over wild-type isolates after fluconazole treatment in a mouse model of vaginal candidiasis. Furthermore, loss of VPS21 does not synergize with established mechanisms of azole resistance, such as overexpression of efflux pumps or of Erg11p, the target enzyme of the azoles. In summary, although loss of VPS21 function enhances C. albicans survival after azole treatment in vitro, it does not seem to affect azole susceptibility in vivo.eng
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherEstados Unidos Antimicrobial Agents and Chemotherapy, 2017.spa
dc.relation.ispartofArticulo de revistaspa
dc.rightsDerechos Reservados - Universidad de Sucre, 2019spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourcehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444139/spa
dc.titleAn azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis.spa
dc.typeArtículo de revistaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.identifier.doi10.1128/AAC.00084-17spa
dc.relation.referencesWhite TC. 1997. Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrob Agents Chemother 41:1482–1487.spa
dc.relation.referencesSanglard D, Ischer F, Monod M, Bille J. 1997. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143: 405–416. https://doi.org/10.1099/00221287-143-2-405.spa
dc.relation.referencesGoldway M, Teff D, Schmidt R, Oppenheim AB, Koltin Y. 1995. Multidrug resistance in Candida albicans: disruption of the BENr gene. Antimicrob Agents Chemother 39:422– 426. https://doi.org/10.1128/ AAC.39.2.422.spa
dc.relation.referencesPerea S, Lopez-Ribot JL, Kirkpatrick WR, McAtee RK, Santillan RA, Martinez M, Calabrese D, Sanglard D, Patterson TF. 2001. Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 45:2676 –2684. https://doi.org/10.1128/AAC.45.10.2676-2684.2001.spa
dc.relation.referencesWhite TC, Holleman S, Dy F, Mirels LF, Stevens DA. 2002. Resistance mechanisms in clinical isolates of Candida albicans. Antimicrob Agents Chemother 46:1704 –1713. https://doi.org/10.1128/AAC.46.6.1704-1713.2002.spa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.subject.proposalAzolesspa
dc.subject.proposalCandida albicansspa
dc.subject.proposalResistancespa
dc.subject.proposalTolerancespa
dc.subject.proposalVaginal candidiasisspa
dc.subject.proposalVps21pspa
dc.contributor.corporatenameAmerican Society for Microbiology.spa
dc.type.contentTextspa
dc.type.redcolhttp://purl.org/coar/resource_type/c_2df8fbb1spa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa


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