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Loss of C-5 sterol desaturase activity results in increased resistance to azole and echinocandin antifungals in a clinical isolate of Candida parapsilosis.
dc.contributor.author | Rybak, Jeffrey M. | spa |
dc.contributor.author | Luna Tapia, Arturo | spa |
dc.contributor.author | Dickens, C. Michael | spa |
dc.contributor.author | Parker, Josie E. | spa |
dc.contributor.author | Caudle, Kelly E. | spa |
dc.coverage.spatial | Colombia | spa |
dc.date.accessioned | 2019-09-24T20:57:55Z | spa |
dc.date.available | 2019-09-24T20:57:55Z | spa |
dc.date.issued | 2019-09-24 | spa |
dc.identifier.citation | Luna, A., Rybak, J.M., Dickens, C.M., Parker, J.E. & Caudle, K.E. (2017). Loss of C-5 Sterol Desaturase Activity Results in Increased Resistance to Azole and Echinocandin Antifungals in a Clinical Isolate of Candida parapsilosis. Antimicrobial Agents and Chemotherapy .61 (9), 651 – 657. | spa |
dc.identifier.issn | 1098-6596 | spa |
dc.identifier.uri | https://repositorio.unisucre.edu.co/handle/001/790 | spa |
dc.description | Artículo digital. | spa |
dc.description.abstract | Among emerging non-albicans Candida species, Candida parapsilosis is of particular concern as a cause of nosocomial bloodstream infections in neonatal and intensive care unit patients. While fluconazole and echinocandins are considered effective treatments for such infections, recent reports of fluconazole and echinocandin resistance in C. parapsilosis indicate a growing problem. The present study describes a novel mechanism of antifungal resistance in this organism affecting susceptibility to azole and echinocandin antifungals in a clinical isolate obtained from a patient with prosthetic valve endocarditis. Transcriptome analysis indicated differential expression of several genes in the resistant isolate, including upregulation of ergosterol biosynthesis pathway genes ERG2, ERG5, ERG6, ERG11, ERG24, ERG25, and UPC2. | eng |
dc.format.mimetype | application/pdf | spa |
dc.language.iso | eng | spa |
dc.publisher | Estados Unidos : Antimicrobial Agents and Chemotherapy, 2017. | spa |
dc.relation.ispartof | Articulo de revista | spa |
dc.rights | Derechos Reservados - Universidad de Sucre, 2019 | spa |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | spa |
dc.source | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571332/ | spa |
dc.title | Loss of C-5 sterol desaturase activity results in increased resistance to azole and echinocandin antifungals in a clinical isolate of Candida parapsilosis. | spa |
dc.type | Artículo de revista | spa |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
dc.type.driver | info:eu-repo/semantics/article | spa |
dc.type.version | info:eu-repo/semantics/publishedVersion | spa |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | spa |
dc.identifier.doi | https://doi.org/10.1128/AAC .00651-17 | spa |
dc.relation.references | Pfaller MA, Andes DR, Diekema DJ, Horn DL, Reboli AC, Rotstein C, Franks B, Azie NE. 2014. Epidemiology and outcomes of invasive candidiasis due to non-albicans species of Candida in 2,496 patients: data from the Prospective Antifungal Therapy (PATH) registry 2004-2008. PLoS One 9:e101510. https://doi.org/10.1371/journal.pone.0101510. | spa |
dc.relation.references | Lockhart SR, Iqbal N, Cleveland AA, Farley MM, Harrison LH, Bolden CB, Baughman W, Stein B, Hollick R, Park BJ, Chiller T. 2012. Species identification and antifungal susceptibility testing of Candida bloodstream isolates from population-based surveillance studies in two U.S. cities from 2008 to 2011. J Clin Microbiol 50:3435–3442. https://doi.org/10 .1128/JCM.01283-12. | spa |
dc.relation.references | Cleveland AA, Farley MM, Harrison LH, Stein B, Hollick R, Lockhart SR, Magill SS, Derado G, Park BJ, Chiller TM. 2012. Changes in incidence and antifungal drug resistance in candidemia: results from population-based laboratory surveillance in Atlanta and Baltimore, 2008-2011. Clin Infect Dis 55:1352–1361. https://doi.org/10.1093/cid/cis697. | spa |
dc.relation.references | Trofa D, Gacser A, Nosanchuk JD. 2008. Candida parapsilosis, an emerging fungal pathogen. Clin Microbiol Rev 21:606–625. https://doi.org/10.1128/CMR.00013-08. | spa |
dc.relation.references | Garcia-Effron G, Katiyar SK, Park S, Edlind TD, Perlin DS. 2008. A naturally occurring proline-to-alanine amino acid change in Fks1p in Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis accounts for reduced echinocandin susceptibility. Antimicrob Agents Chemother 52:2305–2312. https://doi.org/10.1128/AAC.00262-08. | spa |
dc.rights.creativecommons | Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) | spa |
dc.subject.proposal | Candida | spa |
dc.subject.proposal | Antifungal resistance | spa |
dc.subject.proposal | Antimicrobial activity | spa |
dc.subject.proposal | Antimicrobial agents | spa |
dc.subject.proposal | Ergosterol | spa |
dc.subject.proposal | Molecular genetics | spa |
dc.subject.proposal | Mycology | spa |
dc.contributor.corporatename | American Society for Microbiology. | spa |
dc.type.content | Text | spa |
dc.type.redcol | http://purl.org/coar/resource_type/c_2df8fbb1 | spa |
oaire.accessrights | http://purl.org/coar/access_right/c_abf2 | spa |
oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | spa |