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Endosomal Trafficking Defects Can Induce Calcium-Dependent Azole Tolerance in Candida albicans.
(Estados Unidos: Antimicrobial Agents and Chemotherapy , 2016., 2019-09-26)
The azole antifungals arrest fungal growth through inhibition of ergosterol biosynthesis. We recently reported that a Candida albicans vps21 / mutant, deficient in membrane trafficking through the late endosome/prevacuolar ...
An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis.
(Estados Unidos Antimicrobial Agents and Chemotherapy, 2017., 2019-09-24)
We recently reported that a Candida albicans endosomal trafficking mutant continues to grow after treatment with the azole antifungals. Herein, we report that the vps21Δ/Δ mutant does not have a survival advantage over ...