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ERG2 and ERG24 are required for normal vacuolar physiology as well as candida albicans pathogenicity in a murine model of disseminated but not vaginal candidiasis.
(Estados Unidos: Eukaryotic Cell, 2015., 2019-10-01)
Several important classes of antifungal agents, including the azoles, act by blocking ergosterol biosynthesis. It was recently reported that the azoles cause massive disruption of the fungal vacuole in the prevalent human ...
Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals.
(Estados Unidos: Antimicrobial Agents and Chemotherapy , 2015., 2019-10-02)
The purpose of this study was to characterize the effects of azole treatment upon the integrity of the Candida albicans vacuole and to determine whether, in turn, vacuolar trafficking influences azole susceptibility. ...