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ERG2 and ERG24 are required for normal vacuolar physiology as well as candida albicans pathogenicity in a murine model of disseminated but not vaginal candidiasis.
(Estados Unidos: Eukaryotic Cell, 2015., 2019-10-01)
Several important classes of antifungal agents, including the azoles, act by blocking ergosterol biosynthesis. It was recently reported that the azoles cause massive disruption of the fungal vacuole in the prevalent human ...
Loss of C-5 sterol desaturase activity results in increased resistance to azole and echinocandin antifungals in a clinical isolate of Candida parapsilosis.
(Estados Unidos : Antimicrobial Agents and Chemotherapy, 2017., 2019-09-24)
Among emerging non-albicans Candida species, Candida parapsilosis is of particular concern as a cause of nosocomial bloodstream infections in neonatal and intensive care unit patients. While fluconazole and echinocandins ...
Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals.
(Estados Unidos: Antimicrobial Agents and Chemotherapy , 2015., 2019-10-02)
The purpose of this study was to characterize the effects of azole treatment upon the integrity of the Candida albicans vacuole and to determine whether, in turn, vacuolar trafficking influences azole susceptibility. ...
Endosomal Trafficking Defects Can Induce Calcium-Dependent Azole Tolerance in Candida albicans.
(Estados Unidos: Antimicrobial Agents and Chemotherapy , 2016., 2019-09-26)
The azole antifungals arrest fungal growth through inhibition of ergosterol biosynthesis. We recently reported that a Candida albicans vps21 / mutant, deficient in membrane trafficking through the late endosome/prevacuolar ...
Three prevacuolar compartment Rab GTPases impact candida albicans hyphal growth.
(Estados Unidos: Eukaryotic Cell , 2013., 2019-10-03)
Disruption of vacuolar biogenesis in the pathogenic yeast Candida albicans causes profound defects in polarized hyphal growth. However, the precise vacuolar pathways involved in yeast-hypha differentiation have not been ...
In Vivo Indicators of Cytoplasmic, Vacuolar, and Extracellular pH Using pHluorin2 in Candida albicans.
(Estados Unidos: mSphere, 2017., 2019-09-24)
Environmental or chemically induced stresses often trigger physiological
responses that regulate intracellular pH. As such, the capacity to detect pH changes
in real time and within live cells is of fundamental importance ...
An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis.
(Estados Unidos Antimicrobial Agents and Chemotherapy, 2017., 2019-09-24)
We recently reported that a Candida albicans endosomal trafficking mutant continues to grow after treatment with the azole antifungals. Herein, we report that the vps21Δ/Δ mutant does not have a survival advantage over ...
