Eco-epidemiological analysis of rickettsial seropositivity in rural areas of Colombia: A multilevel approach.
Quintero V., Juan C. | 2019-09-25
Rickettsiosis is a re-emergent infectious disease without epidemiological surveillance in
Colombia. This disease is generally undiagnosed and several deadly outbreaks have been
reported in the country in the last decade. The aim of this study is to analyze the eco-epidemiological aspects of rickettsial seropositivity in rural areas of Colombia where outbreaks of the disease were previously reported. A cross-sectional study, which included 597 people living in 246 households from nine hamlets in two municipalities of Colombia, was conducted from November 2015 to January 2016. The survey was conducted to collect sociodemographic and household characteristics (exposure) data. Blood samples were collected to determine the rickettsial seropositivity in humans, horses and dogs (IFA, cut-off = 1/128). In addition, infections by rickettsiae were detected in ticks from humans and animals by realtime PCR targeting gltA and ompA genes.