Browsing FAA. Investigaciones Biomédicas by Author "American Society for Microbiology."
Now showing items 1-5 of 5
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An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis.
Peters, Brian M.; Luna Tapia, Arturo; Tournu, Héléne; Rybak, Jeffrey M.; Rogers, David P.; Palmer, Glen E. (Estados Unidos Antimicrobial Agents and Chemotherapy, 2017., 2019-09-24)We recently reported that a Candida albicans endosomal trafficking mutant continues to grow after treatment with the azole antifungals. Herein, we report that the vps21Δ/Δ mutant does not have a survival advantage over ... -
ERG2 and ERG24 are required for normal vacuolar physiology as well as candida albicans pathogenicity in a murine model of disseminated but not vaginal candidiasis.
Luna Tapia, Arturo; Peters, Brian M.; Eberle, Karen E.; Kerns, Morgan E.; Palmer, Glen E.; Foster, Timothy P.; Marrero, Luis; Noverr, Mairi C.; Fidel , Paul L. (Estados Unidos: Eukaryotic Cell, 2015., 2019-10-01)Several important classes of antifungal agents, including the azoles, act by blocking ergosterol biosynthesis. It was recently reported that the azoles cause massive disruption of the fungal vacuole in the prevalent human ... -
In Vivo Indicators of Cytoplasmic, Vacuolar, and Extracellular pH Using pHluorin2 in Candida albicans.
Tournu, Heléne; Luna Tapia, Arturo; Peters, Brian M.; Palmer, Glen E. (Estados Unidos: mSphere, 2017., 2019-09-24)Environmental or chemically induced stresses often trigger physiological responses that regulate intracellular pH. As such, the capacity to detect pH changes in real time and within live cells is of fundamental importance ... -
Loss of C-5 sterol desaturase activity results in increased resistance to azole and echinocandin antifungals in a clinical isolate of Candida parapsilosis.
Rybak, Jeffrey M.; Luna Tapia, Arturo; Dickens, C. Michael; Parker, Josie E.; Caudle, Kelly E. (Estados Unidos : Antimicrobial Agents and Chemotherapy, 2017., 2019-09-24)Among emerging non-albicans Candida species, Candida parapsilosis is of particular concern as a cause of nosocomial bloodstream infections in neonatal and intensive care unit patients. While fluconazole and echinocandins ... -
Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals.
Luna Tapia, Arturo; Kerns, Morgan E.; Jursic, Branko S.; Eberle, Karen E.; Palmer, Glen E. (Estados Unidos: Antimicrobial Agents and Chemotherapy , 2015., 2019-10-02)The purpose of this study was to characterize the effects of azole treatment upon the integrity of the Candida albicans vacuole and to determine whether, in turn, vacuolar trafficking influences azole susceptibility. ...