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ERG2 and ERG24 are required for normal vacuolar physiology as well as candida albicans pathogenicity in a murine model of disseminated but not vaginal candidiasis.
(Estados Unidos: Eukaryotic Cell, 2015., 2019-10-01)
Several important classes of antifungal agents, including the azoles, act by blocking ergosterol biosynthesis. It was recently reported that the azoles cause massive disruption of the fungal vacuole in the prevalent human ...
In Vivo Indicators of Cytoplasmic, Vacuolar, and Extracellular pH Using pHluorin2 in Candida albicans.
(Estados Unidos: mSphere, 2017., 2019-09-24)
Environmental or chemically induced stresses often trigger physiological
responses that regulate intracellular pH. As such, the capacity to detect pH changes
in real time and within live cells is of fundamental importance ...
An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis.
(Estados Unidos Antimicrobial Agents and Chemotherapy, 2017., 2019-09-24)
We recently reported that a Candida albicans endosomal trafficking mutant continues to grow after treatment with the azole antifungals. Herein, we report that the vps21Δ/Δ mutant does not have a survival advantage over ...